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However,recent evidence indicates that a specific reductase enzyme,present in leishmania amastigots, reduces pentavalent-Sb of SSG to the toxic trivalent form, which thenpromotes efflux of glutathione and other reduced thiolsfrom the parasite residing within macrophages, exposingthem to oxidative damage. The Lozano laboratory explored embryos during various days of gesta-tion and reported 22 % showed empty deciduae concluding that Mdm2 loss trig-gered embryonic lethality around gestational day 5.5

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